货号：06-017

品牌：Merck Millipore

规格：EA

目录价：￥3144.00

市场价格：￥2672.40

会员价格：￥2515.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LRP6 Antibody, C-Terminus | 06-017 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LRP6 at the C-terminus. View All» Molecular Weight: ~181 kDa View All» Epitope: Antibody recognizes C-terminus of LRP6. View All» Immunogen: KLH conjugated linear peptide corresponding to the C-terminus of LRP6. View All» Background Information: Low density lipoprotein receptor-related protein 6, also known as LRP6, is a member of the low density Lipoprotein receptor gene family (LDLR). LDLR are cell surface proteins. LRP6 plays a crucial role in embryonic development by functioning as a co-receptor for the Wnt signaling pathway. LRP6 is highly homologous and presents itself as a dimer in the cell membrane until it is phosphlorylated by Wnt. LRP6 has a high affinity with the Dickkopf (DKK) family of antagonists which, when bound, block Wnt. When LRP6 binds to Wnt it is phosphlorated at multiple sites, which results in Axin, a scaffolding protein, being recruited to the cell membrane and β-catenin activation. β-catenin prevents Wnt and LRP6 from binding. LRP6 is associated with autosomal dominant coronary artery disease type 2. Mutations resulting in the omission of the extracellular domain of LPR6 results in constant activity whereas carboxy intracellular domain exclusion has a negative effect, resulting in the blocking of Wnt signaling. View All» Species Reactivity: Human View All» Species Reactivity Note: Tested on human cells. View All» Application Notes: Western Blot Analysis: A previous lot of this antibody was used in western blot on 293 cell lysate. View All» Control: Malignant melanocytes, fibrous muscularis surrounding ovarian cancer tissue. View All» Quality Assurance: Routinely evaluated by immunohistochemistry on fibrous muscularis surrounding ovarian cancer tissue.Immunohistochemistry (paraffin): Representative lot data.Optimal Staining with Citrate Buffer, pH 6.0, epitope retrieval: Human ovarian cancer tissue. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.09% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: O75581 View All» Entrez Gene Number: NP_002327 View All» Gene Symbol:

• ADCAD2

• FLJ90062;

• FLJ90421

• LRP6
  View All» Alternate Names: Low density lipoprotein receptor-related protein 6 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry (Paraffin)

  • Western Blotting
    View All» Entrez Gene Summary: The LRP6 gene encodes a member of the low density lipoprotein receptor (LDLR) gene family, which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDLR proteins are comprised of the same basic structural motifs: an extracellular domain that contains LDLR binding repeats and EGF repeats with associated spacer domains containing the YWTD motif; a single transmembrane-spanning domain; and a C-terminal cytoplasmic domain that generally contains at least 1 copy of the NPXY motif (Brown et al., 1998 [PubMed 9704021]). LRP6 and LRP5 (MIM 603506) function as coreceptors for WNT (MIM 164820) ligands and thus play a role in WNT signaling, which is important in a wide variety of biologic processes during pre- and postnatal life in invertebrates and vertebrates (Kokubu et al., 2004 [PubMed 15469977]).[supplied by OMIM] View All» UniProt Summary: Function: Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis. Ref.3Subunit structure Interacts with RSPO1 and RSPO3 By similarity. Interacts with FZD5. Essential component of the Wnt7 receptor complex. Wnt7A interacts with the LRP6/FZD5 complex. This interaction is antagonized by DKK1 and DKK3.Subcellular location: Membrane; Single-pass type I membrane proteinPotential. Tissue specificity Widely co-expressed with LRP5 during embryogenesis and in adult tissues.Domain: The YWTD-EGF-like domains 1 and 2 are required for the interaction with Wnt-frizzled complex. The YWTD-EGF-like domains 3 and 4 are required for the interaction with DKK1. Ref.3Involvement in disease: Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2) [MIM:610947]. Ref.6Sequence similarities: Belongs to the LDLR family.Contains 4 EGF-like domains.Contains 3 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats. View All» Product Name: Anti-LRP6, C-Terminus View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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