货号：06-006

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR1 Antibody, C-terminus | 06-006 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminal domain of TLR1. View All» Molecular Weight: ~90 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated synthetic peptide corres-ponding to the C-terminal region of TLR1. View All» Background Information: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR1 recognizes peptidoglycan and (triacyl) lipoproteins on pathogens, especially gram-positive bacteria. TLR1 is found on the surface of macrophages and neutrophils. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by western blot on Raji cell lysate.Western Blot Analysis: 1 μg/mL of this antibody was used to detect TLR1 in Raji cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q15399 View All» Entrez Gene Number: NP_003254.2 View All» Gene Symbol:

• CD281

• DKFZp547I0610

• DKFZp564I0682

• KIAA0012

• MGC104956

• MGC126311

• MGC126312

• TIL

• rsc786
  View All» Alternate Names:
  • CD281 antigen

  • Toll/interleukin-1 receptor-like

  • Toll/interleukin-1 receptor-like protein

  • toll-like receptor 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.SUBUNIT STRUCTURE:Binds MYD88 via their respective TIR domains By similarity. Interacts with TLR2 via its extracellular domain. Ligand binding induces the formation of a heterodimer with TLR2.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane proteinBy similarity. Cytoplasmic vesicle › phagosome membrane; Single-pass type I membrane proteinBy similarity. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.SIMILARITY: Belongs to the Toll-like receptor family.Contains 8 LRR (leucine-rich) repeats.Contains 1 TIR domain. View All» Product Name: Anti-TLR1, C-terminus View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-134182.htm
    © Merck Millipore代理06-006 Mouse TLR1 Antibody (C-term)，产品报价联系微信jinshanbio