货号：05-957

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAP Kinase 1/Erk 1 Antibody, CT | 05-957 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: MAP Kinase 1/Erk1 View All» Molecular Weight: 44 kDa View All» Immunogen: synthetic peptide corresponding to rat Erk1, amino acids 346-380 (CGGPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP) View All» Isotype: IgG View All» Species Reactivity:

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot in RIPA lysates of 3T3/NIH cells View All» Purification Method: Protein A purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P28482 View All» Entrez Gene Number: NM_053842, NM_017347 View All» Gene Symbol:
  • MAPK1

  • p38

  • ERK

  • P42MAPK

  • ERK2

  • p40

  • PRKM1

  • p41mapk

  • PRKM2

  • MAPK2

  • p42-MAPK

  • p41

  • ERK-2

  • ERT1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P28482 # Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4).COFACTOR: Magnesium (By similarity).SIZE: 360 amino acids; 41390 Da SUBUNIT: Interacts with MORG1 (By similarity). Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine- kinase activity. Interacts with HSF4.DOMAIN: SwissProt: P28482 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme.SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-MAP Kinase 1/Erk 1 Antibody, CT | 05-957 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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