货号：05-945

品牌：Merck Millipore

规格：EA

目录价：￥3310.00

市场价格：￥2813.50

会员价格：￥2648.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NKG2D Antibody, clone 3.1.1.1 | 05-945 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: NKG2D View All» Molecular Weight: 25-42 kDa View All» Immunogen: 6His-tagged fusion protein corresponding to residues 85-216 of human NKG2D View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot in RIPA lysates from human Natural Killer cells View All» Purification Method: Protein A purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P26718 View All» Entrez Gene Number: NM_007360 View All» Gene Symbol:

• KLRK1

• KLR

• NKG2D

• CD314

• D12S2489E

• NKG2-D
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. View All» UniProt Summary: FUNCTION: SwissProt: P26718 # Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.SIZE: 216 amino acids; 25274 Da SUBUNIT: Homodimer. Interacts with DAP10. The interaction with DAP10 is required for NKG2D cell surface expression.SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.TISSUE SPECIFICITY: Natural killer cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Also detected in gamma-delta cells and CD8+ alpha-beta T-cells.SIMILARITY: SwissProt: P26718 ## Contains 1 C-type lectin domain.MISCELLANEOUS: Structurally distinct families of ligands for mouse and human NKG2D receptors have been characterized. They might be orthologs. View All» Brand Family: Upstate View All» Product Name: Anti-NKG2D Antibody, clone 3.1.1.1 | 05-945 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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