货号：05-923

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-XPG Antibody, clone 8H7 | 05-923 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes XPG. A non-specific protein was also detected, Mr 67kDa. View All» Molecular Weight: 185kDa View All» Immunogen: Recombinant human XPG. View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot analysis. View All» Purification Method: Protein G purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P28715 View All» Entrez Gene Number: NM_000123 View All» Gene Symbol:

• ERCC5

• XPG

• UVDR

• OTTHUMP00000064902

• ERCM2

• XPGC

• COFS3
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P28715 # Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.SIZE: 1186 amino acids; 133307 Da SUBUNIT: Interacts with PCNA.SUBCELLULAR LOCATION: Nucleus.DISEASE: SwissProt: P28715 # Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278870]; also known as xeroderma pigmentosum VII (XP7). XP-G is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. & Defects in ERCC5 are a cause of Cockayne syndrome (CS) [MIM:216400]. CS is an autosomal recessive disease which is characterized by a UV-sensitive skin (without pigmentation abnormalities), neurological dysfunction due to demyelination of neurons and calcification of basal ganglia (psychomotor retardation, deafness, optic atrophy, retinal pigmentation and hyperreflexes), and dysmorphic dwarfism (immature sexual development and microcephaly).SIMILARITY: SwissProt: P28715 ## Belongs to the XPG/RAD2 endonuclease family. XPG subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-XPG Antibody, clone 8H7 | 05-923 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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