货号：05-862

品牌：Merck Millipore

规格：100Ug

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 | 05-862 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Plasminogen (kringles 1-3) View All» Molecular Weight: Mr 88kDa View All» Immunogen: Purified human plasminogen View All» Isotype: IgM View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on human plasminogen View All» Purification Method: DEAE purified View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number: P00747 View All» Entrez Gene Number: NM_000301 View All» Gene Symbol:

• PLG

• DKFZp779M0222

• plasminogen
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Plasminogen (PLG) is a circulating zymogen that is converted to the active enzyme plasmin by cleavage of the peptide bond between arg560 and val561, which is mediated by urokinase (PLAU; MIM 191840) and tissue plasminogen activator (TPA, PLAT; MIM 173370). The main function of plasmin is to dissolve fibrin (see, e.g., FGA, MIM 134820) clots. Plasmin, like trypsin, belongs to the family of serine proteinases (Miyata et al., 1982 [PubMed 6216475]; Forsgren et al., 1987 [PubMed 3030813]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P00747 # Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.SIZE: 810 amino acids; 90569 Da SUBUNIT: Interacts with AMOT and CSPG4 (also true for angiostatin).SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Present in plasma and many other extracellular fluids. It is synthesized in the kidney.DOMAIN: SwissProt: P00747 Kringle domains mediate interaction with CSPG4.PTM: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity). & In the presence of the inhibitor, the activation involves only cleavage after Arg-580, yielding two chains held together by two disulfide bonds. In the absence of the inhibitor, the activation involves additionally the removal of the activation peptide.DISEASE: "SwissProt: P00747 # Defects in PLG are a cause of thrombophilia [MIM:188050]; a form of recurrent thrombosis. & Defects in PLG may be associated with ligneous conjunctivitis [MIM:217090]. Ligneous conjunctivitis is an unusual and rare form of chronic conjunctivitis, characterized by chronic tearing and redness of the conjunctivae. Initially, pseudomembranes form on the palpebral surfaces which then progress to thick nodular masses that replace the normal mucosa. Because the pseudomembranes have a woodlike consistency, the disease is termed ""ligneous"" conjunctivitis. The disease may be associated with pseudomembranous lesions of other mucous membranes in the mouth, nasopharynx, trachea, and female genital tract."SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. & Contains 5 kringle domains. & Contains 1 PAN domain. & Contains 1 peptidase S1 domain.MISCELLANEOUS: Plasmin is inactivated by alpha-2-antiplasmin immediately after dissociation from the clot." View All» Brand Family: Upstate View All» Product Name: Anti-Plasminogen/Angiostatin Antibody, clone GMA-013 | 05-862 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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