货号：05-861

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 | 05-861 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: von Willebrand Factor View All» Molecular Weight: 260kDa View All» Immunogen: Purified human von Willebrand Factor View All» Clone: GMA-022 View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot View All» Purification Method: DEAE purified View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P04275 View All» Entrez Gene Number: NM_000552 View All» Gene Symbol:

• VWF

• F8

• vWF

• VWD

• F8VWF
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. View All» UniProt Summary: FUNCTION: SwissProt: P04275 # Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.SIZE: 2813 amino acids; 309299 Da SUBUNIT: Multimeric. Interacts with F8.SUBCELLULAR LOCATION: Secreted. Note=Localized to storage granules.TISSUE SPECIFICITY: Plasma.DOMAIN: SwissProt: P04275 The von Willebrand antigen 2 is required for multimerization of VWF and for its targeting to storage granules.PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.DISEASE: SwissProt: P04275 # Defects in VWF are associated with various forms of von Willebrand disease (VWD) [MIM:193400, 277480]. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.). Type I VWD is associated with a deficiency of VWF; type II by normal to decreased plasma level of VWF; type III by a virtual absence of VWF. There are subtypes (A to H) of type II VWD; for example: type IIA is characterized by the absence of VWF high molecular weight multimers in plasma.SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain. & Contains 4 TIL (trypsin inhibitory-like) domains. & Contains 3 VWFA domains. & Contains 3 VWFC domains. & Contains 4 VWFD domains. View All» Brand Family: Upstate View All» Product Name: Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022 | 05-861 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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