货号：05-859

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fibrinogen Antibody, clone GMA-035 | 05-859 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: fibrinogen View All» Molecular Weight: Mr 340kDa View All» Immunogen: Purified human fibrinogen View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on human fibrinogen View All» Purification Method: DEAE purified View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number:

• P02671

• P02675

• P02679
  View All» Entrez Gene Number: NM_021871 / NM_005141 / NM_000509 View All» Gene Symbol:
  • FGA

  • MGC119423

  • Fib2

  • MGC119422

  • MGC119425
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P02679 # Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.SIZE: 453 amino acids; 51512 Da SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).SUBCELLULAR LOCATION: Secreted.DOMAIN: SwissProt: P02679 A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon- (gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. & Sulfation of C-terminal tyrosines increases affinity for thrombin.DISEASE:SwissProt: P02679 # Defects in FGG are a cause of thrombophilia. & Defects in FGG are a cause of congenital afibrinogenemia [MIM:202400]. It is a rare autosomal recessive disorder characterized by complete absence of detectable fibrinogen.SIMILARITY: Contains 1 fibrinogen C-terminal domain.MISCELLANEOUS: The gamma-chain carries the main binding site for the platelet receptor. View All» Brand Family: Upstate View All» Product Name: Anti-Fibrinogen Antibody, clone GMA-035 | 05-859 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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