货号：05-840

品牌：Merck Millipore

规格：100Ug

目录价：￥5075.00

市场价格：￥4313.75

会员价格：￥4060.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1 | 05-840 View All» Replaces: 05-840 is a recommended replacement for AB5968 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes IDO (Indoleamine 2,3- Dioxygenase), Mr 42kDa. View All» Molecular Weight: 42 kDa View All» Immunogen: GST fusion protein corresponding to residues 78-184 of human Indoleamine 2,3- Dioxygenase (IDO). Clone 10.1. View All» Clone: 10.1 View All» Isotype: IgG View All» Background Information: Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in the suppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. View All» Application Notes: Immunocytochemistry: A previous lot was used by an independent laboratory in Phoenix cells transfected with an expression vector.Immunohistochemistry: A previous lot of this antibody was used to detect IDO in human retina, primary eye tumor and metastatic liver tumor tissue sections (Chen, P.W., et al. Experimental Eye Research 85(2007) 617-625). View All» Control: Human IFN-gamma stimulated HeLa cell lysates, IFN gamma stimulated human peripheral blood lymphocytes. View All» Quality Assurance: Routinely evaluated by Western Blot on untreated and IFNgamma treated (24 hrs) Hela lysates.Western Blot Analysis: 1:500 dilution of this lot detected IDO on 10 ug of untreated and IFN gamma treated Hela lysates. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P14902 View All» Entrez Gene Number: NP_002155 View All» Gene Symbol:
  • INDO

  • IDO
    View All» Alternate Names:
    • Indoleamine 2,3-dioxygenase

    • Indoleamine-pyrrole 2,3-dioxygenase

    • indole 2,3-dioxygenase

    • indoleamine-pyrrole 2,3 dioxygenase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Gamma-interferon (IFNG; MIM 147570) has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and Chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase (INDO; EC 1.13.11.42). This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P14902 # Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.COFACTOR: Binds 1 heme group per subunit.SIZE: 403 amino acids; 45326 Da SIMILARITY: SwissProt: P14902 ## Belongs to the indoleamine 2,3-dioxygenase family. View All» Brand Family: Upstate View All» Product Name: Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1 | 05-840 View All» Concentration: 0.54 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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        © Merck Millipore代理05-840 Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1;抗IDO（吲哚胺 2,3-双加氧酶）抗体，克隆10.1store at +2℃，产品报价联系微信jinshanbio