货号：05-794

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p40-phox Antibody, clone 1.22 | 05-794 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: p40-phox View All» Molecular Weight: Mr 40kDa View All» Immunogen: GST fusion protein corresponding to full-length human p40-phox protein View All» Isotype: IgG3 View All» Species Reactivity:

• Human

• Rabbit
  View All» Species Reactivity Note: Does not cross-react with bovine or bison View All» Quality Assurance: routinely evaluated by immunoblot on HL-60 RIPA cell lysate or in human neutrophil cytosol View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: PBS with 0.02% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q15080 View All» Entrez Gene Number: NM_013416 View All» Gene Symbol:
  • NCF4

  • SH3PXD4

  • p40-phox

  • OTTHUMP00000043756

  • MGC3810

  • NCF

  • P40PHOX

  • p40phox

  • OTTHUMP00000028736

  • NCF-4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q15080 # Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.SIZE: 339 amino acids; 39032 Da SUBUNIT: p40-PHOX associates primarily with p67-PHOX to form a complex with p47-PHOX.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expression is restricted to hematopoietic cells.SIMILARITY: SwissProt: Q15080 ## Contains 1 PX (phox homology) domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-p40-phox Antibody, clone 1.22 | 05-794 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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