货号：05-765

品牌：Merck Millipore

规格：200Ug

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MLL/HRX Antibody, C-term., clone 9-12 | 05-765 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the C-terminal proteolytic fragment of MLL (MLL^C). View All» Molecular Weight: 180 kDa View All» Immunogen: MBP fusion protein corresponding to residues 3084-3959 of human mixed lineage leukemia (MLL) View All» Clone: 9-12 View All» Isotype: IgG1 View All» Background Information: The acute lymphoblastic leukaemia (ALL)-1 (also known as MLL, HRX, HTRX, and TRX1) gene on human chromosome 11q23 is the site of many locally clustered chromosomal alterations associated with several types of acute leukaemias, including deletions, partial duplications and translocations. Structurally variant proteins derived from the altered gene presumably cause the malignant transformation of early haemopoietic progenitor cells. View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Immunoprecipitation: This antibody is reported to immunoprecipitate MLL^C from nuclear extracts. The N-terminal fragment, MLL^N (300kDa), is also co-immunoprecipitated by this antibody. View All» Control: K562 nuclear extract View All» Quality Assurance: Routinely evaluated by immunoblot on in nuclear extract from K562 cells View All» Purification Method: Protein G purfied View All» Presentation: Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q03164 View All» Entrez Gene Number: NM_005933 View All» Gene Symbol:
  • MLL

  • HRX

  • CXXC7

  • ALL1

  • HTRX1

  • TRX1

  • FLJ11783

  • ALL-1

  • MLL/GAS7

  • HTRX

  • MLL1A
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Chromatin Immunoprecipitation (ChIP)

    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: SwissProt: Q03164 # Possibly acts as a transcriptional regulatory factor.SIZE: 3969 amino acids; 431764 Da SUBUNIT: Interacts with SBF1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Heart, lung, brain and T- and B-lymphocytes.DISEASE: SwissProt: Q03164 # Chromosomal aberrations involving MLL are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with CXXC6. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. & A chromosomal aberration involving MLL may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.SIMILARITY: SwissProt: Q03164 ## Belongs to the TRX/MLL family. & Contains 3 A.T hook DNA-binding domains. & Contains 1 bromo domain. & Contains 1 CXXC-type zinc finger. & Contains 3 PHD-type zinc fingers. & Contains 1 post-SET domain. & Contains 1 SET domain. View All» Brand Family: Upstate View All» Product Name: Anti-MLL/HRX Antibody, C-term., clone 9-12 | 05-765 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-134018.htm
      © Merck Millipore代理05-765 Anti-MLL/HRX Antibody, CT., clone 9-12;store at -20℃，产品报价联系微信jinshanbio