货号：05-762

品牌：Merck Millipore

规格：EA

目录价：￥4660.00

市场价格：￥3961.00

会员价格：￥3728.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Caveolin-1 Antibody, clone 7C8 | 05-762 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: caveolin-1α and caveolin-1β View All» Molecular Weight: ~24kDa (caveolin-1a) and 21kDa (caveolin-1b) View All» Immunogen: Intracellular membrane protein-containing vesicles (containing GLUT4) from rat adipocytes View All» Isotype: IgG2b View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from A431 cells View All» Purification Method: Protein A purfied View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q03135 View All» Entrez Gene Number: NM_001753 View All» Gene Symbol:
  • CAV1

  • MSTP085

  • Caveolin-1.

  • CAV

  • VIP21
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q03135 # May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).SIZE: 178 amino acids; 20472 Da SUBUNIT: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin.SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane.TISSUE SPECIFICITY: In muscle and lung, less so in liver, brain and kidney.PTM: The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.SIMILARITY: SwissProt: Q03135 ## Belongs to the caveolin family. View All» Brand Family: Upstate View All» Product Name: Anti-Caveolin-1 Antibody, clone 7C8 | 05-762 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Target / Localization: Presynaptic View All» Format: Purified View All» Host: Mouse View All»
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