货号：05-755

品牌：Merck Millipore

规格：

目录价：￥4528.00

市场价格：￥3848.80

会员价格：￥3622.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEL-CAM (MUC18 Antibody, CD146), clone A32 | 05-755 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: MEL-CAM is also known as MUC18, CD146, S-Endo-1, or A32 melanoma-associated antigen View All» Specificity: MEL-CAM View All» Molecular Weight: ~113kDa View All» Immunogen: human primary WM902B melanoma cells View All» Clone: A32 View All» Isotype: IgG1κ View All» Species Reactivity: Human Only View All» Quality Assurance: routinely evaluated by immunoblot on SK-Mel-37 melanoma cell lysates View All» Purification Method: Protein G purfied View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P43121 View All» Entrez Gene Number: NM_006500 View All» Gene Symbol:

• MCAM

• MUC18

• Gicerin

• CD146
  View All» Sales Restrictions: Due to license agreement restrictions, this product cannot be purchased for resale. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting

  • Immunocytochemistry

  • Immunohistochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: P43121 # Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.SIZE: 646 amino acids; 71607 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.SIMILARITY: SwissProt: P43121 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 2 Ig-like V-type (immunoglobulin-like) domains. View All» Brand Family: Upstate View All» Product Name: Anti-MEL-CAM (MUC18, CD146), clone A32 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Target / Localization: surface of pericytes from many different human tissues such as bone marrow, adipose, pancreas, and placenta View All» Format: Purified View All» Host: Mouse View All»
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