货号：05-720

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ING1 Antibody, clone CAb3 | 05-720 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: ING1a, ING1b and ING1c View All» Molecular Weight: ~24kDa (a), 35kDa (b) and 47kDa (c) View All» Immunogen: fusion protein corresponding to residues 70-279 of human ING1b View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on nuclear extracts from human brain tumor SNB19 cells View All» Purification Method: Protein G chromatography View All» Presentation: PBS, pH 7.4 and 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q9UK53 View All» Entrez Gene Number: NM_005537 View All» Gene Symbol:

• ING1

• p47ING1a

• p33ING1b

• p33ING1

• p33

• p47

• p24ING1c
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. View All» UniProt Summary: FUNCTION: SwissProt: Q9UK53 # Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.SIZE: 422 amino acids; 46781 Da SUBUNIT: Interacts with TP53.SUBCELLULAR LOCATION: Nucleus (Probable).TISSUE SPECIFICITY: Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.DISEASE:SwissProt: Q9UK53 # Defects in ING1 are a cause of squamous cell carcinoma of the head and neck (HNSCC) [MIM:275355].SIMILARITY: SwissProt: Q9UK53 ## Belongs to the ING family. & Contains 1 PHD-type zinc finger. View All» Brand Family: Upstate View All» Product Name: Anti-ING1 Antibody, clone CAb3 | 05-720 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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