货号：05-717

品牌：Merck Millipore

规格：200Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2 | 05-717 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes adenosine receptor A2A, Mr 43 kDa. View All» Molecular Weight: ~43 kDa View All» Immunogen: 6His-tagged full-length human recombinant A2A receptor. Epitope mapped to SQPLPGER in the third intracellular loop. Clone 7F6-G5-A2. View All» Clone: 7F6-G5-A2 View All» Isotype: IgG2a View All» Background Information: Adenosine receptors, a class of purinergic G-protein coupled receptors with adenosine as endogenous ligands mediate several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The activity of A2A adenosine receptor is mediated by G proteins which activate adenylyl cyclase. It is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB and may suggest a new strategy for using this mechanism in neurodegenerative diseases. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Rabbit

• Canine
  View All» Species Reactivity Note: Human, mouse, rat, rabbit, and dog. Cross-reactivity with guinea pig also reported. View All» Application Notes: Immunohistochemistry: 1 μg/mL of a previous lot detected Adenosine Receptor A2A in paraformaldehyde-fixed mouse brain striatal sections. Not detected in Adenosine Receptor A2A knockout mice.FACS Analysis: A previous lot of this antibody has been reported by an independent laboratory to detect Adenosine Receptor A2A in transfected HEK293 cells (Koshiba, M., 1999). View All» Control: Brain tissue View All» Quality Assurance: Routinely evaluated by immunohistochemistry.Western Blot Analysis: A 1:1000–1:5000 dilution of this lot of antibody detected Adenosine Receptor A2A in HEK293 cells expressing canine A1/A2A receptor chimeras (Rosin, D.L., 1998). View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2ak in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt View All» UniProt Number: P29274 View All» Entrez Gene Number: NM_000675 View All» Gene Symbol:
  • ADORA2A

  • ADORA2

  • RDC8

  • hA2aR
    View All» Alternate Names:
    • adenosine A2 receptor

    • adenosine A2a receptor

    • adenosine receptor subtype A2a
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. View All» UniProt Summary: FUNCTION: SwissProt: P29274 # Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.SIZE: 412 amino acids; 44707 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P29274 ## Belongs to the G-protein coupled receptor 1 family. View All» Brand Family: Upstate View All» Product Name: Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2 | 05-717 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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