货号：05-652

品牌：Merck Millipore

规格：200Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MUC1/episialin Antibody, clone 214D4 | 05-652 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: MUC1/episialin View All» Molecular Weight: none given View All» Immunogen: Fusion protein, human b-gal-episialin/MUC1 repeat domain View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunohistochemistry View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P15941 View All» Entrez Gene Number: NM_182741 View All» Gene Symbol:

• MUC1

• MUC1/ZD

• MUC-1/X

• PEMT

• MUC-1

• Episialin

• episialin

• MUC-1/SEC

• PUM

• EMA

• PEM

• H23AG

• MAM6

• CD227
  View All» Alternate Names:
  • Breast carcinoma-associated antigen DF3

  • Carcinoma-associated mucin

  • Episialin

  • H23AG

  • PEMT

  • Peanut-reactive urinary mucin

  • PUM

  • Polymorphic epithelial mucin

  • PEM

  • Tumor-associated epithelial membrane antigen

  • EMA

  • Tumor-associated mucin

  • CD227
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined. View All» UniProt Summary: FUNCTION: SwissProt: P15941 # Isoform 7 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.SIZE: 1255 amino acids; 122072 Da SUBUNIT: The cleaved form (only the isoform 1) of MUC1 forms a tight heterodimer with the released C-terminal peptide (which is first secreted to be extracellular).SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 5: Secreted. & Isoform 9: Secreted.TISSUE SPECIFICITY: Expressed on ductal epithelial cells and on activated T-cells. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 expressed only in tumoral cells.PTM: Highly glycosylated (N- and O-linked carbohydrates and sialic acid). In the 20 amino acid tandem repeat positions 5 (Ser), 6 (Thr), 14 (Thr), 15 (Ser) and 19 (Thr) are O-glycosylated (GalNAc). The average density of O-glycosylated sites within repeat peptides varies with cell differentiation from about 50% in lactation-associated MUC1 to over 90% in a variety of breast cancer cells. & Isoform 1 and isoform 7 undergoes transphosphorylation on serine and tyrosine residues.SIMILARITY: SwissProt: P15941 ## Contains 1 SEA domain. View All» Brand Family: Upstate View All» Product Name: Anti-MUC1/episialin Antibody, clone 214D4 | 05-652 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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