货号：05-647

品牌：Merck Millipore

规格：200Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tyrosinase Antibody, clone T311 | 05-647 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Tyrosinase View All» Molecular Weight: 70-80kDa View All» Immunogen: Purified recombinant Tyrosinase corresponding to residues 5-456 of human Tyrosinase View All» Clone: T311 View All» Isotype: IgG2a View All» Species Reactivity: Human View All» Application Notes: Not recommended for Immunoprecipitation View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from SK-MEL-19 cells View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P14679 View All» Entrez Gene Number: NM_000372 View All» Gene Symbol:

• TYR

• LB24-AB

• tyrosinase

• OCAIA

• SK29-AB

• OCA1A
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» UniProt Summary: FUNCTION: SwissProt: P14679 # This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.COFACTOR: Binds 2 copper ions per subunit.SIZE: 529 amino acids; 60393 Da SUBCELLULAR LOCATION: Melanosome membrane; Single-pass type I membrane protein.DISEASE: SwissProt: P14679 # Defects in TYR are the cause of oculocutaneous albinism type IA (OCA-IA) [MIM:203100]. OCA-I, also known as tyrosinase negative oculocutaneous albinism, is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes. OCA-I is divided into 2 types: type IA, characterized by complete lack of tyrosinase activity due to production of an inactive enzyme, and type IB characterized by reduced activity of tyrosinase. OCA-IA patients presents with the life-long absence of melanin pigment after birth and manifest increased sensitivity to ultraviolet radiation and to predisposition to skin cancer. & Defects in TYR are the cause of oculocutaneous albinism type IB (OCA-IB) [MIM:606952]; also known as albinism yellow mutant type. OCA-IB patients have white hair at birth that rapidly turns yellow or blond. They manifest the development of minimal- to-moderate amounts of cutaneous and ocular pigment. & Defects in TYR are the cause of oculocutaneous albinism type I temperature-sensitive (OCA-ITS) [MIM:606952]. OCA-ITS patients have white axillary and scalp hair and pigmented arm and leg hair.SIMILARITY: SwissProt: P14679 ## Belongs to the tyrosinase family. View All» Brand Family: Upstate View All» Product Name: Anti-Tyrosinase Antibody, clone T311 | 05-647 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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