货号：05-579

品牌：Merck Millipore

规格：200UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Endostatin Antibody, clone 1837.46 | 05-579 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: endostatin View All» Molecular Weight: Recognizes endostatin, Mr 22kDa. An unidentified protein is also weakly detected at Mr 54kDa. View All» Immunogen: Full-length recombinant murine endostatin View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on 3T3 cell lysates View All» Purification Method: Thiophilic chromatography View All» Presentation: 50mM sodium phosphate, pH 8.0, 0.05% sodium azide, before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P39060 View All» Entrez Gene Number: NM_009929 View All» Gene Symbol:
  • COL18A1

  • MGC74745

  • endostatin

  • KNO

  • FLJ27325
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P39060 # Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.SIZE: 1754 amino acids; 178160 Da SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Present in multiple organs with highest levels in liver, lung and kidney.PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.DISEASE: SwissProt: P39060 # Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.SIMILARITY: SwissProt: P39060 ## Belongs to the multiplexin collagen family. & Contains 1 FZ (frizzled) domain. & Contains 1 TSP N-terminal (TSPN) domain. View All» Brand Family: Upstate View All» Product Name: Anti-Endostatin Antibody, clone 1837.46 | 05-579 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-133868.htm
      © Merck Millipore代理05-579 Anti-Endostatin Antibody, clone 1837.46;store at -20℃，产品报价联系微信jinshanbio