货号：05-566

品牌：Merck Millipore

规格：EA

目录价：￥3372.00

市场价格：￥2866.20

会员价格：￥2697.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-KSR Antibody, clone C3H7 | 05-566 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: Endogenous levels of KSR may be too low to detect by immunoblotting. Immunoprecipitation prior to immunoblotting is recommended for detection of endogenous KSR. Note levels of recombinant KSR in transfected cells may be high enough to be detected by immunoblotting. View All» Specificity: KSR View All» Molecular Weight: 120kDa View All» Immunogen: GST fusion protein corresponding to residues 118-248 of rat KSR. View All» Clone: C3H7 View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoprecipitation of KSR from 3T3/A31 RIPA lysate, subsequent blotting with anti-KSR. View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q8IVT5 View All» Entrez Gene Number: XM_340852 View All» Gene Symbol:
  • KSR1

  • RSU2

  • KSR
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q8IVT5 # Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.SIZE: 921 amino acids; 102032 Da SUBUNIT: Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity).PTM: Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated (By similarity).SIMILARITY: SwissProt: Q8IVT5 ## Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-KSR Antibody, clone C3H7 | 05-566 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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