货号：05-565

品牌：Merck Millipore

规格：100UL

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nucleolin Antibody, clone 3G4B2 | 05-565 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: nucleolin View All» Molecular Weight: 100kDa View All» Immunogen: Nuclear matrix extract from MDCK cells View All» Isotype: IgG View All» Background Information: Nucleolin, also known as C23, is the major nucleolar protein of exponentially growing eukaryotic cells. It is a ubiquitous conserved multi-domain phosphoprotein found in all vertebrate species. Nucleolin contains a specific bipartite nuclear localization signal sequence and three different structural domains. Nucleolin is a multifunctional protein involved in most steps of ribosome biogenesis. Nucleolin has been implicated in chromatin structure, rDNA transcription, rRNA maturation, ribosome assembly, cytokinesis, nucleogenesis, cell proliferation and growth, andnucleo-cytoplasmic transport. Nucleolin also exhibits autodegradation, DNA and RNA helicase activities, and DNA-dependent ATPase activity. Nucleolin activities may be regulated by proteolysis, methylation, ADPribosylation, and phosphorylation by several kinases, including casein kinase II (CK2), p34cdc2, and protein kinase C-ζ. View All» Species Reactivity:

• Canine

• Human

• Monkey
  View All» Control: HeLa nuclear extract View All» Quality Assurance: routinely evaluated by immunoblot on HeLa nuclear extract View All» Purification Method: Unpurified View All» Presentation: mouse culture supernatant containing 0.05% sodium azide prior to the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P19338 View All» Entrez Gene Number: NM_005381 View All» Gene Symbol:
  • NCL

  • FLJ45706

  • nucleolin

  • C23

  • Nucleolin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. View All» UniProt Summary: FUNCTION: SwissProt: P19338 # Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation.SIZE: 710 amino acids; 76614 Da SUBUNIT: Interacts with APTX and NSUN2. Component of the SWAP complex that consists of NPM1, NCL/nucleolin, PARP1 and SWAP70. Component of a complex which is at least composed of HTATSF1/Tat- SF1, the P-TEFb complex components CDK9 and CCNT1, RNA polymerase II, SUPT5H, and NCL/nucleolin.SUBCELLULAR LOCATION: Nucleus, nucleolus.SIMILARITY: SwissProt: P19338 ## Contains 4 RRM (RNA recognition motif) domains. View All» Brand Family: Upstate View All» Product Name: Anti-Nucleolin Antibody, clone 3G4B2 | 05-565 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Culture Supernatant View All» Host: Mouse View All»
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