货号：05-551

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-E2F-3 Antibody, clone PG37 | 05-551 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: E2F-3 View All» Molecular Weight: 58kDa View All» Immunogen: Recombinant full-length human E2F-3 protein View All» Isotype: IgG2a View All» Background Information: E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F 3 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides. View All» Species Reactivity:

• Human

• Mouse
  View All» Control: HeLa nuclear extract View All» Quality Assurance: routinely evaluated by immunoblot on HeLa nuclear extract or mouse 3T3 nuclear extract View All» Purification Method: Protein A purfied View All» Presentation: PBS, pH 7.4 View All» Storage Conditions: 1 year at 2-8°C View All» UniProt Number: O00716 View All» Entrez Gene Number: NM_001949 View All» Gene Symbol:
  • E2F3

  • KIAA0075

  • E2F-3

  • MGC104598

  • DKFZp686C18211
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. View All» UniProt Summary: FUNCTION: SwissProt: O00716 # Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F-3 binds specifically to RB1 protein, in a cell-cycle dependent manner.SIZE: 465 amino acids; 49162 Da SUBUNIT: Component of the DRTF1/E2F transcription factor complex. Binds cooperatively with DP-1 to E2F sites. Interacts with retinoblastoma protein RB1 and related proteins (such as RBL1) that inhibit the E2F transactivation domain. Binds EAPP.SUBCELLULAR LOCATION: Nucleus.SIMILARITY: SwissProt: O00716 ## Belongs to the E2F/DP family. View All» Brand Family: Upstate View All» Product Name: Anti-E2F-3 Antibody, clone PG37 | 05-551 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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