货号：05-509

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p73β Antibody, clone GC15 | 05-509 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: This antibody does not effectively blot p73α, but will immunoprecipitate p73α under non-denaturing conditions View All» Specificity: p73β and p73 splice variants View All» Molecular Weight: 55-66kDa View All» Immunogen: GST fusion corresponding to residues 380-499 of p73 beta View All» Isotype: IgG View All» Species Reactivity:

• Bovine

• Human

• Hamster

• Monkey
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HFF, HEK293, CHO, A431, or Cos-1 cells View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide, before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O15350 View All» Entrez Gene Number: NM_005427 View All» Gene Symbol:
  • TP73

  • p73

  • P73
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Electrophoretic Mobility Shift Assay

    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: O15350 # Participates in the apoptotic response to DNA damage. When overproduced, activates transcription from p53-responsive promoters and induces apoptosis. May be a tumor suppressor protein.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 636 amino acids; 69623 Da SUBUNIT: The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Found in a complex with p53/TP53 and CABLES1. Isoform Beta interacts with WWOX. Interacts with HECW2.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas.DOMAIN: SwissProt: O15350 Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization domain that binds to the ABL tyrosine kinase SH3 domain. & The WW-binding motif mediates interaction with WWOX.PTM: Isoform alpha (but not isoform beta) is sumoylated on Lys- 627, which potentiates proteasomal degradation but does not affect transcriptional activity.DISEASE:SwissProt: O15350 # Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be frequently mutated in human cancers, in contrast to p53. Hemizygosity is observed in neuroblastoma and oligodendroglioma.SIMILARITY: Belongs to the p53 family. MISCELLANEOUS: Activated and stabilized by interaction with RANBP9. View All» Brand Family: Upstate View All» Product Name: Anti-p73β Antibody, clone GC15 | 05-509 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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