货号：05-502

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FRS2/SNT-1 Antibody | 05-502 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: FRS2/SNT-1 in unstimulated cells and phosphorylated FRS2/SNT-1 in NGF-stimulated cells View All» Molecular Weight: non-phosphorylated (68kDa) and phosphorylated (83kDa) View All» Immunogen: Peptide corresponding to residues 283-297 of human FRS2/SNT-1 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoprecipitating FRS2/SNT-1 from NGF-stimulated and unstimulated rat PC-12 RIPA cell lysates, subsequently immunoblotted with the same antibody. View All» Purification Method: Protein G chromatography View All» Presentation: 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide containing 30% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q8WU20 View All» Entrez Gene Number: NM_006654 View All» Gene Symbol:
  • FRS2

  • SNT1

  • FRS2A

  • SNT-1

  • SNT

  • FRS2alpha
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q8WU20 # Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.SIZE: 512 amino acids; 57528 Da SUBUNIT: Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine- phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.SUBCELLULAR LOCATION: Intracytoplasmic membrane. Note=Cytoplasmic, membrane-bound.TISSUE SPECIFICITY: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.PTM: Phosphorylated on tyrosine residues upon stimulation by NGF. & Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination (By similarity).SIMILARITY: SwissProt: Q8WU20 ## Contains 1 IRS-type PTB domain. View All» Brand Family: Upstate View All» Product Name: Anti-FRS2/SNT-1 Antibody | 05-502 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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