货号：05-471

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-erbB-3/HER-3 Antibody, clone H3.105.5 | 05-471 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes erbB-3, Mr 185 kDa, but not EGF receptor, erbB-2/HER-2, or erbB-4/HER-4Antibody ClassIgG1, antibody produced by P3X63Ag8U1 (P3U1) x Balb/c spleen cells. Purified by ammonium sulfate precipitation, Sephacryl S-300 gel filtration and DEAE-52 chromatography. View All» Molecular Weight: 185 kDa View All» Immunogen: Extracellular domain of recombinant human erbB-3/HER-3 oncoprotein. Clone H3.105.5Antibody ClassIgG1, antibody produced by P3X63Ag8U1 (P3U1) x Balb/c spleen cells. Purified by ammonium sulfate precipitation, Sephacryl S-300 gel filtration and DEAE-52 chromatography. View All» Clone: H3.105.5 View All» Isotype: IgG1 View All» Background Information: erbB3 (HER3, c-erbB3) is a receptor tyrosine kinase (RTK). erbB3 is one of four members of the EGFR/ErbB family of receptor tyrosine kinases. The ErbB family of receptors are a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Though erbB3 is membrane bound and can bind its ligand, it does not have an active kinase domain so it can not transmit this signal without first forming a heterodimer with other EGFR family members. This heterodimerization then leads to proliferation and differentiation. erbB3 is also known to bind Phosphoinositide 3-kinase (PI3 Kinase, PI3K) though six tyrosine phosphorylation sites that PI3K can bind to, which results in the activation of Akt/PKB. erbB3 is known to be amplified in numerous cancers including breast and prostate. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse, other species not tested. View All» Application Notes: Immunoprecipitation: Reported to immunoprecipitate unoccupied erbB-3/HER-3 receptors. View All» Control: Widely expressed. View All» Quality Assurance: Routinely evaluated by receptor neutralization.Receptor neutralization assay: 10 µg/mL of this lot blocked heregulin mediated activation of the erbB-3/HER-3 receptor in MCF-7 cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing 10 mM PBS, pH 7.4. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P21860 View All» Entrez Gene Number: NM_001982 View All» Gene Symbol:
  • ERBB3

  • c-erbB-3

  • c-erbB3

  • erbB-3

  • p180-ErbB3

  • p85-sErbB3

  • p45-sErbB3

  • ErbB-3

  • erbB3-S

  • MGC88033

  • HER3

  • MDA-BF-1
    View All» Alternate Names:
    • Tyrosine kinase-type cell surface receptor HER3

    • lethal congenital contracture syndrome 2

    • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Neutralizing
        View All» Entrez Gene Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.SIZE: 1342 amino acids; 148098 Da SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Epithelial tissues and brain.DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-erbB-3/HER-3 Antibody, clone H3.105.5 | 05-471 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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