货号：05-469

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p130 Cas Antibody, clone 8G4-E8 | 05-469 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: p130 CAS View All» Molecular Weight: 130kDa View All» Immunogen: GST fusion to residues 670-896 of rat p130 Cas. View All» Clone: 8G4-E8 View All» Isotype: IgG2a View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from human A431, HFF, mouse 3T3 and rat L929 cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH7.0 and 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q63767 View All» Entrez Gene Number: NM_014567 View All» Gene Symbol:
  • RBL2

  • Rb2

  • P130

  • PRB2

  • RB2

  • p130

  • FLJ26459

  • RBR-2
    View All» Alternate Names:
    • Breast cancer anti-estrogen resistance protein 1

    • CRK-associated substrate
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: Function: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration By similarity.Subunit structure: Forms complexes in vivo with focal adhesion kinase 1, adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with activated CSPG4. Interacts with BCAR3, NPHP1, PTK2B and SH2D3C. Interacts with INPPL1/SHIP2 By similarity.Subcellular location: Cell junction › focal adhesion. Cytoplasm. Note: Localizes at focal adhesions and stress fibers. Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation.Tissue specificity: Widely expressed. Higher expression in lung, intestine and testis.Domain: Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL.A serine-rich region promotes activation of the serum response element (SRE).The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1.Post-translational modification: Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix.Involvement in disease: Note=Appears to have a central function in transformation of some cell types.Sequence similarities: Belongs to the CAS family. Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-p130 Cas Antibody, clone 8G4-E8 | 05-469 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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