货号：05-372

品牌：Merck Millipore

规格：100Ug

目录价：￥5887.00

市场价格：￥5003.95

会员价格：￥4709.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GRB2 Antibody, clone 3F2 | 05-372 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: N-terminal SH3 region of GRB2 View All» Molecular Weight: 23-25kDa View All» Immunogen: Recombinant GRB2/Ash View All» Isotype: IgG1κ View All» Species Reactivity:

• Bovine

• Human

• Hamster

• Mouse

• Rat
  View All» Application Notes: Not recommended for IP. View All» Quality Assurance: routinely evaluated in immunoblot on RIPA lysates of non-stimulated human A431 carcinoma cells, RIPA lysates of mouse 3T3/A31 fibroblasts, rat L6 myoblasts, Chinese hamster ovary cells or bovine brain extract View All» Purification Method: Protein A chromatography View All» Presentation: PBS containing 50% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P62993 View All» Entrez Gene Number: NM_002086 View All» Gene Symbol:
  • GRB2

  • EGFRBP-GRB2

  • HT027

  • ASH

  • MST084

  • MSTP084

  • Grb3-3
    View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P62993 # Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.SIZE: 217 amino acids; 25206 Da SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptors and PDGF receptors via its SH2 domain. Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains. It also seems to interact with RAS in the signaling pathway leading to DNA synthesis. Binds to and translocates the guanine nucleotide exchange factors SOS. Interacts with phosphorylated TOM1L1 and MET. Interacts with the phosphorylated C-terminus of SH2B2. Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation. Interacts with PTPNS1, REPS2 and the syntrophin SNTA1. Interacts with REPS1 and PIK3C2B via its SH3 domains (By similarity). Interacts with HCV NS5A via its SH3 domains. Interacts with CBL and CBLB. Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2.DOMAIN: SwissProt: P62993 The SH3 domains mediate interaction with SHB.SIMILARITY: Belongs to the GRB2/sem-5/DRK family. & Contains 1 SH2 domain. & Contains 2 SH3 domains. View All» Brand Family: Upstate View All» Product Name: Anti-GRB2 Antibody, clone 3F2 | 05-372 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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