货号：05-219

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vav Antibody | 05-219 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: human and murine p95vav and p85vav View All» Molecular Weight: 95 kDa View All» Immunogen: GST-fusion to full length human Vav View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated on RIPA lysates of Jurkat cells View All» Presentation: ascites fluid containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P15498 View All» Entrez Gene Number: NM_005428.2 View All» Gene Symbol:
  • VAV1

  • VAV
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. View All» UniProt Summary: FUNCTION: SwissProt: P15498 # Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.SIZE: 845 amino acids; 98314 Da SUBUNIT: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB.TISSUE SPECIFICITY: Widely expressed in hematopoietic cells but not in other cell types.DOMAIN: SwissProt: P15498 The DH domain is involved in interaction with CCPG1 (By similarity).PTM: Phosphorylated on tyrosine residues.SIMILARITY: Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains.MISCELLANEOUS: 'Vav' stands for the sixth letter of the Hebrew alphabet. View All» Brand Family: Upstate View All» Product Name: Anti-Vav Antibody | 05-219 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Ascites View All» Host: Mouse View All»
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