货号：MABT85

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Link Protein 1 (Crtl1) Antibody, clone 8-A-4 | MABT85 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~35 kDa and ~47 kDa observed View All» Immunogen: Recombinant protein corresponding to rat Link Protein 1 (Crtl1). View All» Clone: 8-A-4 View All» Isotype: IgG1κ View All» Background Information: Link Proteins are found within the proteoglycan aggregate structures of cartilage tissue. Link Protein 1 (Crtl1) stabilizes the association of the proteoglycan monomers against the central core of hyaluronic acid in the extracellular cartilage matrix and versican in cardiac development. Link Protein 1 (Crtl1) has also been shown to be expressed in AV cushion mesenchyme. View All» Species Reactivity:

• Mouse

• Rat

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Mouse, Rat, and Bovine. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 from a representative lot detected Link Protein 1 (Crtl1) in rat catilage tissue.Western Blot Analysis: A representative lot from independent laboratories detected Link Protein 1 (Crtl1) in mouse atrioventricular cushion tissue lysates (Wirrig, E.E., et al. (2007). Dev Biol. 310(2):291-303. Caterson, B., et al. (1985). J Biol Chem. 260(20):11348-11356).Immunocytochemistry Analysis: A representative lot from an independent laboratory detected HAPLN1 in mesothelioma lung cancer cells (Ivanova, A.V. et al. (2009). Clin Can Res. 15(8):2602-2611). View All» Quality Assurance: Evaluated by Immunohistochemistry in mouse cartilage tissue.Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Link Protein 1 (Crtl1) in mouse cartilage tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P03994 View All» Entrez Gene Number: NP_062062 View All» Gene Symbol:
  • Hapln1

  • Crtl1
    View All» Alternate Names:
    • Hyaluronan and proteoglycan link protein 1

    • Cartilage-linking protein 1

    • Cartilage-link protein

    • Proteoglycan link protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunocytochemistry
        View All» Entrez Gene Summary: Stabilizes cartilage proteoglycan/hyaluronic acid aggregates by binding to each component. View All» UniProt Summary: FUNCTION: Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.SEQUENCE SIMILARITIES: Belongs to the HAPLN family. Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 2 Link domains. View All» Product Name: Anti-Link Protein 1 (Crtl1), clone 8-A-4 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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