货号：MABT81

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAM-C Antibody, clone H33 (azide free) | MABT81 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 35 kDa calculated View All» Immunogen: Full length recombinant protein corresponding to mouse JAM-C. View All» Clone: H33 View All» Isotype: IgG2aκ View All» Background Information: Junctional adhesion molecule C (JAM-C) is an adhesion molecule found at endothelial intracellular junctions that plays a role in leukocyte transendothelial migration and other inflammatory events. JAM-C seems to be important in the pathophysiology of pancreatitis and therefore could be a promising clinical target. JAM-C expression has been shown to be increased when T lymphocytes are activated. Research has shown that controlling JAM-C may also be a way of controlling pathological angiogenesis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse based immunogen design. View All» Application Notes: Inhibition of Activity Assay: A representative lot was used by an independent laboratory to inhibit microvessel outgrowth in an adapted mouse aortic ring assay (Lamagna, C., et al. (2005). Cancer Res. 65:5703-5710).Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC (Lamagna, C., et al. (2005). Cancer Res. 65:5703-5710).Functional Blocking: Mice treated with a representative lot of this antibody showed a trend toward a reduced number of leukocytes in the tissue at every time point analyzed (Bradfield, P.F., et al. (2007). Blood, 110(7):2545-2555).Functional Blocking: Mice treated with a representative lot of this antibody showed a trend toward reduced diabetes incidence and blood glucose over time (Christen, S., et al. PLoS ONE. 8(1):e54675) View All» Control: VEGF treated HUVEC cells View All» Quality Assurance: Evaluated by Flow Cytometry in VEGF treated HUVEC cells.Flow Cytometry Analysis: A 1:125 dilution of this antibody detected JAM-C in VEGF treated HUVEC cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in PBS without 0.05% sodium azide (preservative free). View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9D8B7 View All» Entrez Gene Number: NP_075766 View All» Gene Symbol: Jam3 View All» Alternate Names:
  • Junctional adhesion molecule C

  • JAM-C

  • JAM-2

  • Junctional adhesion molecule 3

  • JAM-3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Affects Function
      View All» UniProt Summary: FUNCTION: May participate in cell-cell adhesion distinct from tight junctions. SUBUNIT STRUCTURE: Interacts with JAM2 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICTY: Endothelial cells. SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-JAM-C, clone H33 (azide free) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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