货号：MABT64

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nectin-4/PVRL4 Antibody, clone N4.61 | MABT64 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 55 kDa calculated View All» Immunogen: Recombinant protein corresponding to human Nectin-4. View All» Clone: N4.61.2 View All» Isotype: IgG1κ View All» Background Information: Nectin-4 is also known as poliovirus receptor-related protein 4 (PRR4 or PVRL4). Nectins are known for being the receptors for the herpes simplex virus. Nectin-4 is an immunoglobulin-like transmembrane cell adhesion protein that also seems to play a role in neural tube formation, with N-cadherin. Nectin-4 is connected with the actin cytoskeleton through afadin inside the cell. Nectin-4 is predominantly found in human placenta although in mice, expression is wide-ranging. Nectin-4 seems to adhere primarily to cells expressing nectin-1 and vice versa. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: ELISA Anaysis: A previous lot was used by an independent laboratory in ELISA (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550).Immunoprecipitation Anaysis: A previous lot was used by an independent laboratory in IP (Fabre-Lafay, S., et al. (2005). Journal of Biological Chemistry. 280(20):19543–19550). View All» Control: Ductal carcinoma tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in ductal carcinoma tissue.Immunohistochemistry Analysis: A 1:400 dilution of this antibody detected Nectin-4/PVRL4 in ductal carcinoma tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG1κ Supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96NY8 View All» Entrez Gene Number: NP_112178 View All» Gene Symbol:

• PVRL4

• PRR4

• LNIR
  View All» Alternate Names:
  • poliovirus receptor-related 4

  • Ig superfamily receptor LNIR

  • nectin 4

  • poliovirus receptor-related protein 4

  • nectin-4

  • Nectin-4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • ELISA

    • Immunoprecipitation
      View All» Entrez Gene Summary: Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001 [PubMed 11544254]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.SUBUNIT STRUCTURE: Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein Potential. Cell junction › adherens junction. Note: Colocalizes with MLLT4 at cadherin-based adherens junctions. Processed poliovirus receptor-related protein 4: Secreted. Note: The secreted form is found in breast tumor patients. TISSUE SPECIFICTY: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. PTM: The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.SEQUENCE SIMILARITIES: Belongs to the nectin family.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain. View All» Product Name: Anti-Nectin-4/PVRL4, clone N4.61 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MABT64 Anti-Nectin-4/PVRL4 Antibody, clone N4.61;抗-连接蛋白-4/PVRL4抗体，克隆N4.61store at +2℃ to +8℃，产品报价联系微信jinshanbio