货号：MABT63

品牌：Merck Millipore

规格：50Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nectin-3/PVRL3 (CD113) Antibody, clone N3.12.4 | MABT63 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 61 kDa calculated View All» Immunogen: Full length recombinant protein corresponding to human Nectin-3. View All» Clone: N3.12.4 View All» Isotype: IgG2aκ View All» Background Information: Nectin-3, also known as Poliovirus receptor-related protein 3 (PVRL3) and PRR3, is thought to work with cadherin to form cell-cell adherens junctions. It is a transmembrane protein that is commonly found in the testis and in placental tissue. Nectin-3 colocalizes with CD155, the cognate receptor for poliovirus, to cell-cell junctions. Nectin-3's involvement in down-regulation PVR from the cell surface leads to a reduction in cell motility and proliferation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: U251 cells View All» Quality Assurance: Evaluated by Flow Cytometry in U251 cells.Flow Cytometry Analysis: 0.1 µg of this antibody detected Nectin-3 in U251 cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NQS3 View All» Entrez Gene Number: NP_056295 View All» Gene Symbol:

• CDw113

• PRR3

• PPR3

• CD113

• PVRR3
  View All» Alternate Names:
  • poliovirus receptor-related 3

  • poliovirus receptor-related protein 3

  • nectin 3

  • nectin-3

  • Nectin-3

  • CD113 antigen
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» Entrez Gene Summary: Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells. [supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. SUBUNIT STRUCTURE: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT. SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein Potential. TISSUE SPECIFICTY: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.SEQUENCE SIMILARITIES: Belongs to the nectin family.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 Ig-like V-type (immunoglobulin-like) domain.SEQUENCE CAUTION: The sequence AAH17572.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Nectin-3/PVRL3 (CD113), clone N3.12.4 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Purified View All» Host: Mouse View All»
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