货号：MABT51

品牌：Merck Millipore

规格：50Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Galectin-3 Antibody, clone M3/38 | MABT51 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: 0 View All» Molecular Weight: ~28 kDa observed View All» Immunogen: Plasma membrane glycoproteins corresponding to mouse Galectin-3. View All» Clone: M3/38 View All» Isotype: IgG2aκ View All» Background Information: Galectin-3 belongs to the galectin gene family defined by the specificity of a carbohydrate recognition domain (CRD) for Gal/Lac and expression is usually elevated in a wide range of neoplastic cell types. The galectin CRD consists of 135 amino acids. Galectin-3 has been shown to effect tumor development and progression. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Western Blot Analysis: 1:50,000 dilution from a previous lot detected Galectin-3 in 10 µg of NIH/3T3 cell lysate.Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Springer, T., et al. (1981). THE JOURNAL OF BIOLOGICACHLE MISTRY. 256(8):3833-3839.)Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Gasbarri, A., et al. (1999). Journal of Clinical Oncology. 17(11):3494-3502.)Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC. (Gasbarri, A., et al. (1999). Journal of Clinical Oncology. 17(11):3494-3502.) View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1:50,000 dilution of this antibody detected Galectin-3 in 10 µg of HeLa cell lysate. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P16110 View All» Entrez Gene Number: NP_001139425 View All» Gene Symbol:
  • LGALS3

  • L-31

  • GAL3

  • Galectin-3

  • GALIG

  • MAC2

  • GALBP

  • LGALS2

  • MAC-2

  • CBP35
    View All» Alternate Names:
    • lectin, galactoside-binding, soluble, 3

    • Mac-2 antigen

    • Carbohydrate-binding protein 35

    • galectin-3

    • Galactose-specific lectin 3

    • Laminin-binding protein

    • Lectin L-29

    • IgE-binding protein

    • Galactoside-binding protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunohistochemistry

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). SUBUNIT STRUCTURE: Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. SUBCELLULAR LOCATION: Nucleus. Note: Cytoplasmic in adenomas and carcinomas (By similarity). May be secreted by a non-classical secretory pathway and associate with the cell surface. TISSUE SPECIFICTY: The highest levels are found in activated macrophages.SEQUENCE SIMILARITIES: Contains 1 galectin domain. View All» Product Name: Anti-Galectin-3, clone M3/38 View All» Concentration: 0.5 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 50 µg View All» Format: Purified View All» Host: Rat View All»
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