货号：MABT42

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Integrin beta-2 (CD18) Antibody, clone M18/2 | MABT42 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 85 kDa calculated View All» Immunogen: Whole B10 mouse spleen cells enriched with T-cells. View All» Isotype: IgG2aκ View All» Background Information: Integrin beta-2, also known as CD18, is an adhesion receptor in neutrophils that interacts with cytohesin-1 intracellularly. Integrin beta is instrumental in activation-dependent adhesion and adhesion-dependent signaling. Expression of integrin beta-2 has a positive correlation with patient survival from malignant B cell lymphoma. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP (Sanchez-Madrid, F., et al. (1983). J. ExP. MED. 158:586-602).Inhibition Analysis: A previous lot of this antibody was shown to inhibit lymphoma metastasis (Zahalka, M. A. et al. (1993) J. Immunol. 150, 4466). View All» Control: Mouse EL4 cells View All» Quality Assurance: Evaluated by Flow Cytometry in mouse EL4 cells.Flow Cytometry Analysis: 10 µg of this antibody detected Integrin beta-2 in mouse EL4 cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P11835 View All» Entrez Gene Number: NP_032430 View All» Gene Symbol:

• CD18

• LFA-1

• MAC-1

• CD18

• MF17

• MFI7

• LCAMB

• LAD2
  View All» Alternate Names:
  • integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

  • integrin beta chain, beta 2

  • complement receptor C3 beta-subunit

  • leukocyte cell adhesion molecule CD18

  • integrin beta-2

  • Complement receptor C3 subunit beta

  • Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta

  • leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C

  • CD18 antigen

  • integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1

  • macrophage antigen 1 (mac-1) beta subunit)

  • cell surface adhesion glycoprotein (LFA-1,CR3,P150,959 beta subunit precursor)

  • cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Beta-2 associates with either alpha-L, alpha-M, alpha-X or alpha-D. Interacts with COPS5 and RANBP9 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SEQUENCE SIMILARITIES: Belongs to the integrin beta chain family.Contains 1 VWFA domain. View All» Product Name: Anti-Integrin beta-2 (CD18), clone M18/2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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