货号：MABT14

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytohesin-1 Antibody, clone 7H2 | MABT14 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes Cytohesin-1. View All» Molecular Weight: ~ 46 kDa View All» Epitope: Unknown View All» Immunogen: Histidine-tagged recombinant protein corresponding to human Cytohesin-1. View All» Clone: 7H2 View All» Isotype: IgG1κ View All» Background Information: Cytohesin-1 is a guanine nucleotide exchange factor and an integrin binding protein belonging to a closely related group of proteins known as the cytohesion family. Cytohesin-1 contains 2 domains; a C-terminal, pleckstrin homology (PH) domain, and a central, large Sec7 domain. The PH domain serves to mediate the proteins functional regulation and the reversible membrane recruitment. The Sec7 domain acts as the primary regulator for phosphoinositide-dependent membrane attachment of the protein. Cytohesin-1 appears to have an integral role in integrin alphaLbeta2 adhesive function, and in the activation of integrin mediated pathways involved in wound healing, and immune system cell-cell/ cell-matrix interactions. It is highly expressed in natural killer and peripheral T cells. There are two known isoforms produced by alternative splicing. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Boehm, 2003).Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IP. (Boehm, 2003). View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western blot in Jurkat cell lysate.Western blot Analysis: 0.5 µg/mL of this antibody detected Cytohesin-1 in 10 µg of Jurkat cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15438 View All» Entrez Gene Number: NP_004753 View All» Gene Symbol:

• B2-1

• PSCD1

• CYTH1

• SEC7
  View All» Alternate Names:
  • cytohesin 1

  • cytoadhesin 1

  • CYTOHESIN-1

  • pleckstrin homology, Sec7 and coiled-coil domains 1

  • homolog of secretory protein SEC7

  • PH, SEC7 and coiled-coil domain-containing protein 1

  • SEC7 homolog B2-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunofluorescence

    • Immunoprecipitation
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF through replacement of GDP with GTP.SUBUNIT STRUCTURE: Interacts with TRIM23 and CYTIP. TISSUE SPECIFICITY: Ubiquitous.SEQUENCE SIMILARITIES: Contains 1 PH domain.Contains 1 SEC7 domain. View All» Product Name: Anti-Cytohesin-1, clone 7H2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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