货号：MABT128

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAM-A Antibody, clone BV11 | MABT128 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 32 kDa calculated View All» Immunogen: H5V murine heart capillary endothelial cells. View All» Clone: BV11 View All» Isotype: IgG2bκ View All» Background Information: Junctional adhesion molecule A (JAM-A) is found in endothelial and epithelial tight junctions and is involved in the inflammatory enlistment of mononuclear cells containing LFA-1. JAM-A is linked to atherogenesis, platelet activation, transmigration of leukocytes and angiogenesis. JAM-A is also found to be important in the development of many different organ systems, and is mostly expressed in the epithelial parts and the embryonic vasculature. JAM-A is indicated to play a role in epithelial permeability, inflammation and proliferation in the intestine, aiding in homeostasis. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. View All» Application Notes: Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in cell extracts from Mouse H5V and PDV cells, and in COS cultures transfected with full length cDNA of mouse JAM-A (Martin-Padura, I., et al. (1998). J Cell Biol. 142(1):117-127).Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in cultured epithelial cells, cremaster muscles, and Schwann Cells (Martin-Padura, I., et al. (1998). J Cell Biol. 142(1):117-127). View All» Control: bEnd.3 cells View All» Quality Assurance: Evaluated by Flow Cytometry in bEnd.3 cells. Flow Cytometry Analysis: A 1:1,000 dilution of this antibody detected JAM-A in bEnd.3 cells. View All» Purification Method: Protein G Purified View All» Presentation: Purified rat monocolonal IgG2bκ in buffer containing PBS and no preservatives. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O88792 View All» Entrez Gene Number: NP_766235 View All» Gene Symbol:

• F11r

• Jam1

• Jcam

• Jcam1
  View All» Alternate Names:
  • JAM

  • JAM-1

  • JAM-A

  • Ly06

  • ESTM33

  • AA638916

  • 9130004G24

  • F11r

  • Junctional adhesion molecule 1

  • CD321
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Flow Cytometry

    • Immunocytochemistry

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.SUBUNIT STRUCTURE: Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interaction. Interacts with the orthoreovirus sigma-1 capsid protein.SUBCELLULAR LOCATION: Cell junction › tight junction. Cell membrane; Single-pass type I membrane protein. Note: Localized at tight junctions of both epithelial and endothelial cells. View All» Product Name: Anti-JAM-A, clone BV11 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
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