货号：MABT11

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ZO-1 Antibody, clone R40.76 | MABT11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes ZO-1. View All» Molecular Weight: ~220 kDa View All» Epitope: Unknown View All» Immunogen: Purified protein corresponding to mouse ZO-1. View All» Clone: R40.76 View All» Isotype: IgG2aκ View All» Background Information: Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane associated guanylate kinase (MAGUK) family and include occludin and zona occludin family members ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with rat based on 100% sequence homology. View All» Application Notes: Immunofluorescence Analysis: A previous lot was used by an indepenedent laboratory in IF (D'Angelo Siliciano, 1988). View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by Western blot in mouse brain lysate.Western blot Analysis: 0.5 µg/mL of this antibody detected ZO-1 in 10 µg of mouse brain lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P39447 View All» Entrez Gene Number: NP_033412 View All» Gene Symbol:
  • ZO-1

  • ZO1
    View All» Alternate Names:
    • tight junction protein 1

    • zonula occludens 1 protein

    • Zona occludens protein 1

    • Zonula occludens protein 1

    • zona occludens 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions.SUBUNIT STRUCTURE: Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with CGN/cingulin, CXADR, GJD3, HSPA4 and UBN1 by similarity. Interacts with occludin, claudins, GJA12 and KIRREL1. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side by similarity. Cell junction › tight junction by similarity. Note: Movement of ZO-1 from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact by similarity.DOMAIN: The second PDZ domain mediates interaction with GJA12. SEQUENCE SIMILARITIES: Belongs to the MAGUK family. Contains 1 guanylate kinase-like domain. Contains 3 PDZ (DHR) domains. Contains 1 SH3 domain. Contains 1 ZU5 domain. View All» Product Name: Anti-ZO-1, clone R40.76 View All» Concentration: 0.5mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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