货号：MABS95

品牌：Merck Millipore

规格：

目录价：￥3393.00

市场价格：￥2884.05

会员价格：￥2714.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Wnt-1 Antibody, clone 20C3.1 | MABS95 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~41 kDa observed. Uncharacterized band at ~165 kDa may be observed in some lysates. View All» Immunogen: GST-tagged recombinant protein corresponding to human Wnt-1. View All» Clone: 20C3.1 View All» Isotype: IgMκ View All» Background Information: Wnt-1 was first identified as a proto-oncogene activated by viral insertion in mouse mammary tumors. The Wnt-1 gene encodes a member of a large family of secreted proteins that are cysteine-rich, glycosylated, and poorly soluble. Wnt-1 serves as a ligand for the RYK coreceptor, resulting in Wnt signaling. The Wnt signalling pathway mediates the levels of cytosolic beta-catenin, a multi-functional protein that associates with membrane-bound E-cadherin as well as several DNA-binding proteins, such as members of the TCF/LEF family. Additionally, it serves a ligand for members of the frizzled family of seven transmembrane receptors and plays a role in development of the central nervous system. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with Human, Rat, and Mouse. View All» Application Notes: Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Wnt-1 in human brain tissue lysate. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected Wnt-1 in 10 µg of mouse brain tissue lysate. View All» Purification Method: Purified by ion exchange chromatography View All» Presentation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P04628 View All» Entrez Gene Number: NP_005421 View All» Gene Symbol:
  • WNT1

  • INT1
    View All» Alternate Names:
    • Proto-oncogene Wnt-1

    • Proto-oncogene Int-1 homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. View All» UniProt Summary: FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.SUBUNIT STRUCTURE: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3. Interacts with WLS.SUBCELULLAR LOCATION: Secreted > extracellular space > extracellular matrix. View All» Product Name: Anti-Wnt-1, clone 20C3.1 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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