货号：MABS67

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-erbB-3/HER-3 Antibody, clone 15A2.1 | MABS67 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~185 kDa observed. The calculated molecular weight of this protein is 148 kDa, but can be observed at ~185-200 kDa due to high glycosylation. View All» Immunogen: GST-tagged recombinant protein corresponding to human erbB-3/HER-3. View All» Clone: 15A2.1 View All» Isotype: IgG1κ View All» Background Information: erbB-3/HER-3 is a receptor tyrosine kinase (RTK) and is a member of the EGFR/ErbB family of receptor tyrosine kinases. Four subfamilies make up the ErbB family of receptors: erbB-1 (EGFR), erbB-2 (HER2/c-neu), erbB-3 (HER3), and erbB-4 (HER4). erbB-2 is membrane bound and able to bind its ligand, but it does not have an active kinase domain to transmit this signal. In order to transmit the signal, erbB-3 must first form a heterodimer with other ErbB family memebers. This heterodimerization then leads to proliferation and differentiation. erbB-2 also binds Phosphoinositide 3 Kinase (PI3K) through six tyrosine phosphorylation sites that PI3K can bind resulting in the activation of AKT/PKB. erbB-3 has been shown to be amplified in numerous types of cancer, including breast and prostate. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected erbB-3/HER-3 on 10 µg of NIH/3T3 cell lysate. View All» Control: MCF-7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF-7 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected erbB-3/HER-3 on 10 µg of MCF-7 cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P21860 View All» Entrez Gene Number: NP_001005915 View All» Gene Symbol:
  • ERBB3

  • HER3
    View All» Alternate Names:
    • Receptor tyrosine-protein kinase erbB-3

    • Proto-oncogene-like protein c-ErbB-3

    • Tyrosine kinase-type cell surface receptor HER3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: Binds and is activated by neuregulins and NTAK.SIZE: 1342 amino acids; 148098 Da SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Epithelial tissues and brain.DOMAIN: The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).DISEASE: Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain. View All» Product Name: Anti-erbB-3/HER-3, clone 15A2.1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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