货号：MABS62

品牌：Merck Millipore

规格：100Ug

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GREB1 Antibody, clone GREB1Ab | MABS62 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 216 kDa observed. Uncharacterized bands may be observed in some lysates. View All» Immunogen: Recombinant protein corresponding to human GREB1. View All» Clone: GREB1Ab View All» Isotype: IgG1κ View All» Background Information: GREB1, also known as gene regulated in breast cancer protein 1 is shown to be involved in the proliferation of breast cancer cells, controlled by estrogen. GREB1 has the potential to be a clinical marker for response to endocrine therapy and a therapeutic target. GREB1 also may be the regulator for prostate cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: 1:600 dilution from a previous lot detected GREB1 in prostate tissue.Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IP. (Hnatyszyn, H., et al. 2009). Breast Cancer Res TreatDOI 10.1007/s10549-009-0584-x.) View All» Control: MCF-7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF-7 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GREB1 on 10 µg of MCF-7 cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q4ZG55 View All» Entrez Gene Number: NP_055483 View All» Gene Symbol: GREB1 View All» Alternate Names:

• growth regulation by estrogen in breast cancer 1

• Gene regulated in breast cancer 1 protein

• protein GREB1

• gene regulated by estrogen in breast cancer protein
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Unknown. Primary target for estrogen receptor regulation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). TISSUE SPECIFICTY: Expressed in proliferating prostatic tissue and prostate cancer.INDUCTION: Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements. SEQUENCE SIMILARITIES: Belongs to the GREB1 family.SEQUENCE CAUTION: The sequence BAA25501.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-GREB1, clone GREB1Ab View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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