货号：MABS55

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CTMP Antibody, clone BH1-52F11 | MABS55 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~27 kDa observed View All» Immunogen: Recombinant protein corresponding to human CTMP. View All» Clone: BH1-52F11 View All» Isotype: IgG1κ View All» Background Information: Carboxyl-terminal modulator protein (CTMP) is a known binding partner of protein kinase B (PKB; also known as AKT) and has been shown to regulate both phosphorylation and activation of PKB. Early studies have shown the nature of CTMP’s regulation of PKB to be negative; however more recent studies have shown overexpression of CTMP to cause it to act as a positive inducer of PKB activation and phosphorylation. CTMP expression has been observed in testis, brain, uterus, skeletal muscle, and kidney with lower levels seen in the liver, lung and heart. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: MCF7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in MCF7 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Carboxyl-terminal modulator protein on 10 µg of MCF7 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q5T1C6 View All» Entrez Gene Number: NP_444283 View All» Gene Symbol:

• CTMP

• THEM4
  View All» Alternate Names:
  • thioesterase superfamily member 4

  • C-terminal modulator protein

  • Carboxyl-terminal modulator protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq]. View All» Key Applications:
    • Western Blotting

    • ELISA
      View All» UniProt Summary: FUNCTION: According to Ref.1, inhibits AKT1 phosphorylation and activity. According to Ref.7, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. (Ref. 1: PubMed: 11598301) (Ref 7: PubMed: 17615157).SUBUNIT STRUCTURE: Interacts with AKT1. SUBCELLULAR LOCATION: Cell membrane. Cell projection › ruffle membrane. Cytoplasm TISSUE SPECIFICITY: Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. PTM: Phosphorylated. View All» Product Name: Anti-CTMP, clone BH1-52F11 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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