货号：MABS35

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GSTMu1 Antibody, clone CPTC-GSTMu1-5 | MABS35 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 23 kDa observed View All» Immunogen: Full length recombinant protein corresponding to human GSTMu1. View All» Clone: GSTMu1-5 View All» Isotype: IgG1κ View All» Background Information: GSTMu1 (Glutathione S-transferase Mu 1) is involved in the inactivation of a large spectrum of carcinogens that are ever-present in the environment. GSTMu1 has been found to be a negative regulator of MEKK1 activity after cellular stress. GSTMu1 has also been shown to inhibit the activity of apoptosis signal-regulating kinase 1 (ASK1), and may have an additional function of regulating stress-mediated signals. Recently GSTMu1 has been linked to increased airway inflammation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (Tara Hitke, Developmental Studies Hybridoma Bank, University of Iowa.) View All» Control: Human liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human liver tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected GSTMu1 on 10 µg of human liver tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P09488 View All» Entrez Gene Number: NP_000552 View All» Gene Symbol:

• H-B

• MU

• GTH4

• GTM1

• GSTM1a-1a

• MU-1

• GSTM1b-1b

• GSTM1-1

• GST1

• GSTM1
  View All» Alternate Names:
  • glutathione S-transferase mu 1

  • glutathione S-transferase M1

  • glutathione S-alkyltransferase

  • S-(hydroxyalkyl)glutathione lyase

  • HB subunit 4

  • GST class-mu 1

  • glutathione S-aryltransferase2

  • GST HB subunit 4

  • glutathione S-aralkyltransferase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.SUBUNIT STRUCTURE: Homodimer.SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICTY: Liver (at protein level). POLYMORPHISM: There are two alleles; GSTM1A and GSTM1B which differ in position 173.SEQUENCE SIMILARITIES: Belongs to the GST superfamily. Mu family.Contains 1 GST C-terminal domain.Contains 1 GST N-terminal domain. View All» Product Name: Anti-GSTMu1, clone CPTC-GSTMu1-5 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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