货号：MABS196

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mTOR/FRAP, clone 22C2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~290 kDa observed View All» Immunogen: Linear peptide corresponding to human mTOR/FRAP. View All» Clone: 22C2 View All» Isotype: IgG1κ View All» Background Information: The mammalian target of rapamycin (mTOR), also known as FRAP, RAFT, or RAPT, is a ubiquitously expressed serine/threonine kinase that belongs to the phosphoinositide 3-kinase–related kinase (PIKK) family. mTOR functions as a downstream effector in the PI3K pathway and is activated by the Akt kinase. mTOR responds to signals from growth factors and promotes protein synthesis underlying cell proliferation, by activation of the S6 kinase and inhibition of the 4E-BP protein involved in protein translation. Several studies have suggested that the proliferative functions of mTOR may contribute to the development of cancer. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A representative lot was used by an independent laboratory in neuroblastoma cells. (Hosoi, H., et al. (1998). Molecular Pharmacology. 54:815–824.)Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in Rho30 cell extracts. (Hosoi, H., et al. (1998). Molecular Pharmacology. 54:815–824.) View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected mTOR/FRAP on 10 µg of Jurkat cell lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P42345 View All» Entrez Gene Number: NP_004949 View All» Gene Symbol:

• MTOR

• FRAP

• FRAP1

• FRAP2

• RAFT1

• RAPT1
  View All» Alternate Names:
  • Serine/threonine-protein kinase mTOR

  • FK506-binding protein 12-rapamycin complex-associated protein 1

  • FKBP12-rapamycin complex-associated protein

  • Mammalian target of rapamycin

  • mTOR

  • Mechanistic target of rapamycin

  • Rapamycin and FKBP12 target 1

  • Rapamycin target protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Product Name: Anti-mTOR/FRAP, clone 22C2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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