货号：MABS168

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dab2 Antibody, clone EP2297Y, Rabbit | MABS168 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes Dab2 at the C-terminus. View All» Molecular Weight: ~105 kDa observed View All» Epitope: C-terminus View All» Immunogen: Synthetic peptide corresponding to human Dab2 at the C-terminus. View All» Clone: EP2297Y View All» Isotype: IgG View All» Background Information: Disabled-2 (Dab2) is a component of the CSF-1 signal transduction pathway. Dab2 is involved in the regulation of cytoskeleton based functions by regulating cell positioning, inducing marcrophage adhesion, or regulation of protein trafficking of endocytosis involved proteins (1,2). Dab2 has been implicated in regulating the homeostasis of epithelial differentiation, where Dab2 is involved in endodermal cell formation, differentiation, and organization. Dab2 mRNA expression is common in normal ovarian epithelia cells but low or lack of expression is seen in ovarian carcinoma cell lines (3). View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunocytochemistry Analysis: A 1:100-1:250 dilution from a representative lot was used in IC. Immunoprecipitation Analysis: A 1:20 dilution from a representative lot was used in IP.Flow Cytometry Analysis: A 1:50 dilution from a representative lot was used in FC. View All» Control: Human pancreas tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human pancreas tissue lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected Dab2 in human pancreas tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P98082 View All» Entrez Gene Number: P98082 View All» Gene Symbol:

• DOC-2

• DOC2

• FLJ26626

• OTTHUMP00000221142
  View All» Alternate Names:
  • disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

  • Differentially-expressed protein 2

  • disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)

  • disabled homolog 2

  • mitogen-responsive phosphoprotein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Flow Cytometry

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Component of the CSF-1 signal transduction pathway By similarity.SUBUNIT STRUCTURE: Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN By similarity. SUBCELLULAR LOCATION: Cytoplasmic vesicle › clathrin-coated vesicle membrane. Membrane › clathrin-coated pit. Note: Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. TISSUE SPECIFICITY: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine. SEQUENCE SIMILARITIES: Contains 1 PID domain. View All» Product Name: Anti-Dab2, clone EP2297Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
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