货号：MABS167

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Dab1 Antibody, clone EP2248Y, Rabbit | MABS167 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes Dab1 at Ser491. View All» Molecular Weight: ~80 kDa observed View All» Epitope: Ser491 View All» Immunogen: Synthetic peptide corresponding to human Dab1 at Ser491. View All» Clone: EP2248Y View All» Isotype: IgG View All» Background Information: Disabled-1 (Dab1) regulates laminar organization in the developing mammalian brain. Although mutation of the disabled-1 gene in scrambler mice results in abnormalities in neuronal positioning, migratory behavior linked to Dab1 signaling is not completely understood. Results outline the molecular mechanism by which Dab1 signaling controls the adhesive property of neurons to radial glia, thereby maintaining proper neuronal positioning during corticogenesis (1). Reelin is a large extracellular protein secreted by pioneer neurons that coordinates cell positioning during neurodevelopment. Dab1 is a phosphoprotein that appears to function as an intracellular adaptor in protein kinase pathways. Expression analysis indicates that mdab1 is expressed in neuronal populations exposed to Reelin. The similar phenotypes of reeler, scrambler, yotari and mdab1 null mice indicate that Reelin and Dab1 function as signaling molecules that regulate cell positioning in the developing brain (2). Layering of neurons in the cerebral cortex and cerebellum requires Reelin, Dab1 as well as two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) (3). View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain tissue lysate.Western Blot Analysis: A 1:2,000 dilution of this antibody detected Dab1 in rat brain tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit Monoclonal in buffer containing 40% Glycerol, 50mM Tris-Glycine (pH 7.4), 0.01% sodium azide and 0.05% BSA. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: O75553 View All» Entrez Gene Number: O75553 View All» Gene Symbol:
  • OTTHUMP00000010045

  • OTTHUMP00000011753

  • OTTHUMP00000011801
    View All» Alternate Names:
    • disabled homolog 1 (Drosophila)

    • disabled (Drosophila) homolog 1

    • disabled homolog 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Adapter molecule functioning in neural development. May regulate SIAH1 activity By similarity.SUBUNIT STRUCTURE: Associates with the SH2 domains of SRC, FYN and ABL. Interacts with DAB2IP and SIAH1 By similarity. Interacts with LRP1.DOMAIN: The PID domain specifically binds to the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins.PTM: Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons By similarity. Also phosphorylated on Ser-524 independently of reelin signaling By similarity.SEQUENCE SIMILARITIES: Contains 1 PID domain.SEQUENCE CAUTION: The sequence BAE06094.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Dab1, clone EP2248Y, Rabbit Monoclonal View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-133160.htm
      © Merck Millipore代理MABS167 Anti-Dab1, clone EP2248Y, Rabbit Monoclonal，产品报价联系微信jinshanbio