货号：MABS15

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRS-2 Antibody, clone 9.5.2 | MABS15 View All» Replaces: 06-506 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IRS-2. View All» Molecular Weight: ~ 185 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse IRS-2. View All» Clone: 9.5.2 View All» Isotype: IgG1κ View All» Background Information: Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this family have been identified that differ as to tissue distribution, subcellular localization, developmental expression, binding to the insulin receptor, and interaction with SH2 domain-containing proteins. In fact, IRS-1 appears to have its major role in skeletal muscle whereas IRS-2 appears to regulate hepatic insulin action as well as pancreatic beta cell development and survival. By contrast, IRS-3 and IRS-4 genes appear to play a redundant role in the IRS signaling system. Defects in muscle IRS-1 expression and function have been reported in insulin-resistant states such as obesity and type 2 diabetes. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with rat based on 100% sequence homology. View All» Control: Insulin treated CHO IR/IRS-2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in Insulin treated CHO IR/IRS-2 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected IRS-2 on 10 µg of Insulin treated CHO IR/IRS-2 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P81122 View All» Entrez Gene Number: NP_001074681.1 View All» Gene Symbol:
  • IRS2

  • IRS-2
    View All» Alternate Names: insulin receptor substrate 2 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May mediate the control of various cellular processes by insulin.TISSUE SPECIFICITY: Skeletal muscle, lung, brain, liver, kidney, heart and spleen.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR by similarity. SEQUENCE SIMILARITIES: Contains 1 IRS-type PTB domain.Contains 1 PH domain. View All» Product Name: Anti-IRS-2, clone 9.5.2 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-133153.htm
    © Merck Millipore代理MABS15 Anti-IRS-2 Antibody, clone 9.5.2;store at +2℃ to +8℃，产品报价联系微信jinshanbio