货号：MABS110

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SGK2 Antibody, clone 3D1 | MABS110 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SGK2. View All» Molecular Weight: 41 kDa View All» Immunogen: GST-tagged recombinant protein corresponding to human SGK2. View All» Clone: 3D1 View All» Isotype: IgG3κ View All» Background Information: Serine/threonine protein kinase SGK2 (SGK2) is a serine/threonine protein kinase belonging to the AGC Ser/Thr protein kinase family and is involved in potassium channel activation. SGK2 contains two domains of interest; an AGC-kinase C-terminal domain containing Ser-416, and a protein kinase domain containing Thr-253. Phosphorylation of Ser-416 and Thr-253 is necessary to the activation of SGK2. Alternative splice variants results in three known isoforms. The highest expression of SGK2 has been observed in kidney, liver and pancreas, while lower levels have been noted in brain tissue. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with mouse. Predicted to react with human based on 100% sequence homology. View All» Control: Mouse liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse liver tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected SGK2 on 10 µg of mouse liver tissue lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG3κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HBY8 View All» Entrez Gene Number: NP_057360 View All» Gene Symbol:
  • H-SGK22

  • SGK2
    View All» Alternate Names:
    • serum/glucocorticoid regulated kinase 2

    • Serum/glucocorticoid-regulated kinase 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Involved in the activation of potassium channels. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.ENZYME REGULATION: Two specific sites, one in the kinase domain (Thr-253) and the other in the C-terminal regulatory region (Ser-416), need to be phosphorylated for its full activation.TISSUE SPECIFICITY: Highly expressed in liver, kidney and pancreas, and at lower levels in brain. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Caution Not regulated by serum or glucocorticoids. View All» Product Name: Anti-SGK2, clone 3D1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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