货号：MABN77

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Potassium Channel Kv1.2 Antibody, clone K14/16 | MABN77 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 65 kDa observed View All» Immunogen: Recombinant protein corresponding to rat Kv1.2. View All» Clone: K14/16 View All» Isotype: IgG2bκ View All» Background Information: Potassium channel Kv1.2 is one of many different types of potassium channels in the cell. The Kv family of potassium channels seem to have a conserved homotetramer formation consisting of four voltage sensors and one pore domain. Kv1.2 cooperates with cortactin (an actin cytoskeleton-binding protein) and together they may have a part in the regulation of the ionic current. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Application Notes: Immunofluorescence Analysis: a previous lot of this antibody was used by an independent laboratory in IF. (Yang, J.W., et al. (2007). PNAS. 104(50):20055–20060.) View All» Control: Rat brain membrane tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Kv1.2 on 10 µg of rat brain membrane tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P63142 View All» Entrez Gene Number: NP_037102 View All» Gene Symbol:

• KCNA2

• HBK5

• RBK2

• HK4

• MK2

• KV1.2

• NGK1

• HUKIV

• Kv1.2
  View All» Alternate Names:
  • potassium voltage-gated channel, shaker-related subfamily, member 2

  • potassium voltage-gated channel subfamily A member 2

  • Voltage-gated potassium channel subunit Kv1.2

  • Voltage-gated potassium channel HBK5

  • potassium channel

  • Voltage-gated K(+) channel HuKIV

  • voltage-gated potassium channel protein Kv1.2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting

    • Immunofluorescence
      View All» Entrez Gene Summary: Delayed-rectifier K+ channel expressed in heart and brain [RGD]. View All» UniProt Summary: FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.SUBUNIT STRUCTURE: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. DOMAIN: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.SEQUENCE SIMILARITIES: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. [View classification] View All» Product Name: Anti-Potassium Channel Kv1.2, clone K14/16 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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      © Merck Millipore代理MABN77 Anti-Potassium Channel Kv1.2 Antibody, clone K14/16;store at +2℃ to +8℃，产品报价联系微信jinshanbio