货号：MABN75

品牌：Merck Millipore

规格：EA

目录价：￥3828.00

市场价格：￥3253.80

会员价格：￥3062.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pick1 Antibody, clone L20/8 | MABN75 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 47 kDa observed. The ~ 90 kDa band could be the homodimer. View All» Epitope: 0 View All» Immunogen: Recombinant protein corresponding to rat Pick1. View All» Clone: L20/8 View All» Isotype: IgG2aκ View All» Background Information: Pick1 is thought to be involved in the organization and localization of a number of membrane proteins (such as AMPA receptors) containing the PDZ recognition sequence. It has been shown that Pick1 binds phosphoinositide lipids using the Bin/amphiphysin/Rvs (BAR) domain. This step is critical for the targeting function of Pick1, its ability to move AMPA receptors to membrane surfaces and the induction of long-term signal depression. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Control: Rat brain membrane tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Pick1 on 10 µg of rat brain membrane tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9EP80 View All» Entrez Gene Number: NP_445912 View All» Gene Symbol:

• PICK1

• Pick1

• PRKCABP

• PICK
  View All» Alternate Names:
  • protein interacting with PRKCA 1

  • Protein kinase C-alpha-binding protein

  • protein interacting with PRKCA

  • protein kinase C, alpha binding protein

  • PRKCA-binding protein

  • Protein interacting with C kinase 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: PDZ domain containing protein; interacts with C-terminal domain of many central nervous system receptor proteins; may have an important role in signal transduction during synaptic transmission [RGD]. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. May be regulated upon PRKCA activation. May regulate ACCN3/ACCN2 channel.SUBUNIT STRUCTURE: Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ACCN1 and ACCN2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR By similarity. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. SUBCELLULAR LOCATION: Cytoplasm › perinuclear region. Membrane; Peripheral membrane protein. Note: Also membrane-associated, present at excitatory synapses.TISSUE SPECIFICTY: Ubiquitous.DEVELOPMENTAL STAGE: Expressed early in development (E15), and gradually increases, reaching a peak at around 2 weeks after birth.PTM: Phosphorylated (By similarity).SEQUENCE SIMILARITIES: Contains 1 AH domain.Contains 1 PDZ (DHR) domain. View All» Product Name: Anti-Pick1, clone L20/8 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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