货号：MABN54

品牌：Merck Millipore

规格：EA

目录价：￥3948.00

市场价格：￥3355.80

会员价格：￥3158.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-pan-SAPAP Antibody, clone N127/31 | MABN54 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: Isoforms between ~90-120 kDa observed. Other isoforms may be observed in some lysates. View All» Immunogen: Recombinant protein corresponding to rat SAPAP. View All» Clone: N127/31 View All» Isotype: IgG2bκ View All» Background Information: SAPAP1 is a member of the SAPAP family of proteins and is thought to be instrumental in the postsynaptic scaffold of neurons. SAPAP1 may function to assemble various other proteins at synapses. These functional proteins include scaffolding proteins, signaling proteins and cytoskeletal proteins. SAPAP1 is primarily found in the brain and more specifically in the cell body zones. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected SAPAP in rat schwan cells (putamen area) and rat dopaminergic neurons.Immunofluorescence Analysis: A previous lot of this antibody was used by an independent laboratory in cultured rat hippocampal pyramidal cells and interneurons. (Courtesy of Dieter Edbauer and Morgan Sheng, Picower Institute, MIT.) View All» Control: Rat brain membrane tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain membrane tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected SAPAP on 10 µg of rat brain membrane tissue lysate. View All» Purification Method: Protein G View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P97836 View All» Entrez Gene Number: NP_075235 View All» Gene Symbol:

• DLGAP1

• GKAP

• DAP-1-BETA

• DAP-1

• SAPAP1

• DAP-1-ALPHA

• hGKAP

• DAP1
  View All» Alternate Names:
  • discs, large (Drosophila) homolog-associated protein 1

  • SAP90/PSD-95-associated protein 1

  • disks large-associated protein 1

  • Guanylate kinase-associated protein

  • PSD-95/SAP90 binding protein 1

  • PSD-95/SAP90-binding protein 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: binds the guanylate kinase-like domain of the PSD-95 family of synaptic ion channel clustering proteins; may play a role in protein-protein interactions at the synaptic junction [RGD]. View All» UniProt Summary: FUNCTION: Part of the postsynaptic scaffold in neuronal cells.SUBUNIT STRUCTURE: Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG3, DLG4 and AIP1. Interacts with the PDZ domain of SHANK1, SHANK2 and SHANK3. Found in a complex with DLG4 and SHANK1, SHANK2 or SHANK3. Found in a complex with DLG4 and BEGAIN. Interacts with DYL2 and LRFN1. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Cell junction › synapse. Note: Found in postsynaptic density of neuronal cells.TISSUE SPECIFICTY: Expressed in brain and testis.DEVELOPMENTAL STAGE: Highest level of isoform 1 in the brain of newborn rats. Increasing levels of isoforms 2, 3, 4, and 5 in the brain of newborn rats from birth to 6 weeks of postnatal development. Increasing but low level of isoform 6 is expressed in the brain from 2 to 6 weeks of postnatal development. SEQUENCE SIMILARITIES: Belongs to the SAPAP family. View All» Product Name: Anti-pan-SAPAP, clone N127/31 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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