货号：MABN499

品牌：Merck Millipore

规格：100Ug

目录价：￥4192.00

市场价格：￥3563.20

会员价格：￥3353.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AMIGO-1 Antibody, clone L86/33 | Cat. No. MABN499 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody reacts with the C-terminus of AMIGO-1. This antibody does not demonstrate cross-reactivity with AMIGO-2 and AMIGO-3. View All» Molecular Weight: ~70 kDa observed. The calculated molecular weight of this protein is 55 kDa, but is observed between ~60-80 kDa due to glycosylation. The dimerization of AMIGO-1 is observed at ~140 kDa (Kajander, T., et al. (2011). J Mol Biol. 413(5):1001-1015). View All» Epitope: C-terminus View All» Immunogen: Recombinant protein corresponding to human AMIGO-1. View All» Clone: L86/33 View All» Isotype: IgG2aκ View All» Background Information: Amphoterin-induced protein 1 (AMIGO-1), also known as Alivin-2, is a transmembrane protein that has been demonstrated to promote fasciculation of neurite outgrowths in cultured hippocampal neurons. AMIGO-1 forms homodimers and also heterodimerizes with AMIGO-2 and AMIGO-3, and may contribute to signal transduction through its intracellular domain, mediate cell-cell interaction, and may also play a role in neuronal regeneration and plasticity in the adult nervous system. View All» Species Reactivity:

• Rat

• Human
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected AMIGO-1 in rat cerebral cortex and hippocampus tissue. A 1:500 dilution from a representative lot detected AMIGO-1 in human pons/midbrain tissues.Western Blot Analysis: A representative lot detected AMIGO-1 in rat brain membrane tissue extract and in COS cell lysates transiently transfected with V5-tagged AMIGO-1.Immunohistochemistry Analysis: A representative lot detected AMIGO-1 in rat brain membrane tissue and in WT mouse brain tissue, but demonstrated a loss of signal in AMIGO-1 knockout mouse brain tissue. View All» Control: Rat brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat brain tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected AMIGO-1 in 10 µg of rat brain tissue lysate. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q86WK6 View All» Entrez Gene Number: NP_065754 View All» Gene Symbol:
  • AMIGO1

  • ALI2

  • AMIGO
    View All» Alternate Names:
    • Amphoterin-induced protein 1

    • AMIGO-1

    • Alivin-2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Product Name: Anti-AMIGO-1, clone L86/33 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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